The most remarkable aspect of living tissue is their ability to maintain mechanical integrity as they are submitted to external forces such as those implicated in tissue remodelling (cell intercalation, cell migration, cell polarisation). The maintenance of such an integrity is a critical feature for tissue homeostasis and highly depends on the regulation of cell adhesion, shape and contractility.

Conversely, several pathologies, such as metastasis dissemination, asthma, or sickle cell anemia, are systematically associated with the alteration of the mechanical properties of a given cell type.

@ Lab, we are currently developing a combination of micropatterned substrates, optical technics and traction force microscopy in order to understand how mechanical forces are sensed and generated by eucaryotic cells.

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